Identification of drug resistance mutations among Mycobacterium bovis lineages in the Americas.

ABSTRACT: Identifying the Mycobacterium tuberculosis resistance mutation patterns is of the utmost importance to assure proper patient's management and devising of control programs aimed to limit spread of disease. Zoonotic Mycobacterium bovis infection still represents a threat to human health, particularly in dairy production regions. Routinary, molecular characterization of M. bovis is performed primarily by spoligotyping and mycobacterial interspersed repetitive units (MIRU) while next generation sequencing (NGS) approaches are often performed by reference laboratories. However, spoligotyping and MIRU methodologies lack the resolution required for the fine characterization of tuberculosis isolates, particularly in outbreak settings. In conjunction with sophisticated bioinformatic algorithms, who

SUBMITTER: Vazquez-Chacon CA 

PROVIDER: S-EPMC7886168 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature