Libman-Sacks endocarditis and associated cerebrovascular disease: The role of medical therapy.

ABSTRACT:

Background

Libman-Sacks endocarditis in patients with systemic lupus erythematosus (SLE) is commonly complicated with embolic cerebrovascular disease (CVD) or valve dysfunction for which high-risk valve surgery is frequently performed. However, the role of medical therapy alone for Libman-Sacks endocarditis and associated acute CVD remains undefined.

Objective

To determine in this cross-sectional and longitudinal study if conventional anti-inflammatory and anti-thrombotic therapy may be an effective therapy in SLE patients with Libman-Sacks endocarditis and associated acute CVD.

Methods and materials

17 SLE patients with Libman-Sacks endocarditis detected by two-and-three-dimensional transesophageal echocardiography (TEE) and complicated with acute CVD [stroke/TIA, fo

SUBMITTER: Roldan CA 

PROVIDER: S-EPMC7886205 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature