Leisure-Time and Occupational Physical Activity Associates Differently with Epigenetic Aging.

ABSTRACT:

Purpose

Greater leisure-time physical activity (LTPA) associates with healthier lives, but knowledge regarding occupational physical activity (OPA) is more inconsistent. DNA methylation (DNAm) patterns capture age-related changes in different tissues. We aimed to assess how LTPA and OPA are associated with three DNAm-based epigenetic age estimates, namely, DNAm age, PhenoAge, and GrimAge.

Methods

The participants were young adult (21-25 yr, n = 285) and older (55-74 yr, n = 235) twin pairs, including 16 pairs with documented long-term LTPA discordance. Genome-wide DNAm from blood samples was used to compute DNAm age, PhenoAge, and GrimAge Age acceleration (Acc), which describes the difference between chronological and epigenetic ages. Physical activity was assessed with spor

SUBMITTER: Kankaanpaa A 

PROVIDER: S-EPMC7886335 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature