Tumor-associated neutrophils (TANs) in human carcinoma-draining lymph nodes: a novel TAN compartment.

ABSTRACT:

Objectives

The role of tumor-associated neutrophils (TANs) in the nodal spread of cancer cells remains unexplored. The present study evaluates the occurrence and clinical significance of human nodal TANs.

Methods

The relevance, derivation, phenotype and interactions of nodal TANs were explored via a large immunohistochemical analysis of carcinoma-draining lymph nodes, and their clinical significance was evaluated on a retrospective cohort of oral squamous cell carcinomas (OSCC). The tumor-promoting function of nodal TAN was probed in the OSCC TCGA dataset combining TAN and epithelial-to-mesenchymal transition (EMT) signatures.

Results

The pan-carcinoma screening identified a consistent infiltration (59%) of CD66b⁺  TANs in tumor-draining lymph nodes

SUBMITTER: Lonardi S 

PROVIDER: S-EPMC7886597 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature