Antibiofilm Activity of Small-Molecule ZY-214-4 Against Staphylococcus aureus.

ABSTRACT: Staphylococcus aureus is the most important pathogenic bacteria in humans. As the resistance of S. aureus to existing antibiotics is increasing, there is an urgent need for new anti-infective drugs. S. aureus biofilms cause persistent infections and resist complete eradication with antibiotic therapy. The present study investigated the inhibitory effect of the novel small-molecule ZY-214-4 (C_{1 9}H_{1 1}BrNO₄) on S. aureus biofilm formation. At a subinhibitory concentration (4 μg/ml), ZY-214-4 had no effect on the growth of S. aureus strains and also showed no cytotoxicity in human normal bronchial epithelial cells (Bease-2B). The results of a semi-quantitative biofilm test showed that ZY-214-4 prevented <

SUBMITTER: Yu J 

PROVIDER: S-EPMC7886693 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature