The Role of Cytoplasmic MEX-5/6 Polarity in Asymmetric Cell Division.

ABSTRACT: In the process of asymmetric cell division, the mother cell induces polarity in both the membrane and the cytosol by distributing substrates and components asymmetrically. Such polarity formation results from the harmonization of the upstream and downstream polarities between the cell membrane and the cytosol. MEX-5/6 is a well-investigated downstream cytoplasmic protein, which is deeply involved in the membrane polarity of the upstream transmembrane protein PAR in the Caenorhabditis elegans embryo. In contrast to the extensive exploration of membrane PAR polarity, cytoplasmic polarity is poorly understood, and the precise contribution of cytoplasmic polarity to the membrane PAR polarity remains largely unknown. In this study, we explored the interplay between the cytoplasmic MEX-5/6 polar

SUBMITTER: Seirin-Lee S 

PROVIDER: S-EPMC7886744 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature