Identification of Hub Genes and Immune Infiltration in Psoriasis by Bioinformatics Method.

ABSTRACT:

Background

Psoriasis is a chronic, prolonged, and recurrent skin inflammatory disease. However, the pathogenesis of psoriasis is not completely clear, thus we aimed to explore potential molecular basis of it.

Methods

Two datasets were downloaded from the Gene Expression Omnibus database. After identifying the differentially expressed genes of psoriasis skin lesion samples and healthy controls, three kinds of analyses, namely functional annotation, protein-protein interaction (PPI) network, and immune infiltration analyses, were performed.

Results

A total of 152 up-regulated genes and 38 down-regulated genes were selected for subsequent analyses. Evaluation of the PPI network identified the most important module containing 13 hub genes. Gene ontology analysis showed th

SUBMITTER: Su W 

PROVIDER: S-EPMC7886814 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature