Intertissue small RNA communication mediates the acquisition and inheritance of hormesis in Caenorhabditis elegans.

ABSTRACT: Environmental conditions can cause phenotypic changes, part of which can be inherited by subsequent generations via soma-to-germline communication. However, the signaling molecules or pathways that mediate intertissue communication remain unclear. Here, we show that intertissue small RNA communication systems play a key role in the acquisition and inheritance of hormesis effects - stress-induced stress resistance - in Caenorhabditis elegans. The miRNA-processing enzyme DRSH-1 is involved in both the acquisition and the inheritance of hormesis, whereas worm-specific Argonaute (WAGO) proteins, which function with endo-siRNAs, are involved only in its inheritance. Further analyses demonstrate that the miRNA production system in the neuron and the small RNA transport machinery in the intestine

SUBMITTER: Okabe E 

PROVIDER: S-EPMC7886853 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature