Colorimetric detection of individual biothiols by tailor made reactions with silver nanoprisms.

ABSTRACT: We herein described a rapid, sensitive, and selective colorimetric sensing platform for biothiols in human serum, which relies on the dual functions of biothiols as anti-etching and aggregating agent for silver nanoprisms (AgNPRs). In principle, the target biothiols that bind to the surface of AgNPRs through Ag-S covalent interactions protect the AgNPRs from being etched by chloride ion (Cl^-) in human serum, thus exhibiting the blue/purple color that is indicative of AgNPRs. On the other hand, the color of AgNPRs turned to yellow in the absence of biothiols or the presence of non-sulfur-containing amino acids, indicating the formation of small silver nanoparticles (AgNPs). Importantly, we found that individual biothiols (Hcy, Cys, and GSH) exert not only the anti-etching effect,

SUBMITTER: Li P 

PROVIDER: S-EPMC7886879 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature