Stellate cell computational modeling predicts signal filtering in the molecular layer circuit of cerebellum.

ABSTRACT: The functional properties of cerebellar stellate cells and the way they regulate molecular layer activity are still unclear. We have measured stellate cells electroresponsiveness and their activation by parallel fiber bursts. Stellate cells showed intrinsic pacemaking, along with characteristic responses to depolarization and hyperpolarization, and showed a marked short-term facilitation during repetitive parallel fiber transmission. Spikes were emitted after a lag and only at high frequency, making stellate cells to operate as delay-high-pass filters. A detailed computational model summarizing these physiological properties allowed to explore different functional configurations of the parallel fiber-stellate cell-Purkinje cell circuit. Simulations showed that, following parallel fiber sti

SUBMITTER: Rizza MF 

PROVIDER: S-EPMC7886897 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature