Genome-wide association study reveals a novel locus for asthma with severe exacerbations in diverse populations.

ABSTRACT:

Background

Severe asthma exacerbations are a major cause of asthma morbidity and increased healthcare costs. Several studies have shown racial and ethnic differences in asthma exacerbation rates. We aimed to identify genetic variants associated with severe exacerbations in two high-risk populations for asthma.

Methods

A genome-wide association study of asthma in children and youth with severe exacerbations was performed in 1283 exacerbators and 2027 controls without asthma of Latino ancestry. Independent suggestive variants (P ≤ 5 × 10^-6 ) were selected for replication in 448 African Americans exacerbators and 595 controls. Case-only analyses were performed comparing the exacerbators with additional 898 Latinos and 524 African Americans asthma patients without exa

SUBMITTER: Herrera-Luis E 

PROVIDER: S-EPMC7886969 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature