Identification of Regulatory circRNAs Involved in the Pathogenesis of Acute Myocardial Infarction.

ABSTRACT:

Background

Acute myocardial infarction (AMI) has high morbidity and mortality worldwide. However, the pathogenesis of AMI is still unclear, and the impact of circular RNAs (circRNAs) on AMI has rarely been recognized and needs to be explored.

Materials and methods

The circRNA array was applied to investigate the expression level of circRNAs in the blood samples of coronary arteries of three AMI patients and three normal persons. Principal component analysis (PCA) and unsupervised clustering analysis were performed to reveal the distinguished expression patterns of circRNAs. The miRNA expression profiles of AMI patients were identified from a public dataset from the Gene Expression Omnibus (GEO) database (GSE31568). The miRNA binding sites on the circRNAs were predicted by mi

SUBMITTER: Zhao C 

PROVIDER: S-EPMC7886988 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature