Frontline Science: OX40 agonistic antibody reverses immune suppression and improves survival in sepsis.

ABSTRACT: A defining feature of protracted sepsis is development of immunosuppression that is thought to be a major driving force in the morbidity and mortality associated with the syndrome. The immunosuppression that occurs in sepsis is characterized by profound apoptosis-induced depletion of CD4 and CD8 T cells and severely impaired T cell function. OX40, a member of the TNF receptor superfamily, is a positive co-stimulatory molecule expressed on activated T cells. When engaged by OX40 ligand, OX40 stimulates T cell proliferation and shifts the cellular immune phenotype toward TH1 with increased production of cytokines that are essential for control of invading pathogens. The purpose of the present study was to determine if administration of agonistic Ab to OX40 could reverse sepsis-induced immuno

SUBMITTER: Unsinger J 

PROVIDER: S-EPMC7887130 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature