Liver Fibrosis and Perihematomal Edema Growth in Primary Intracerebral Hemorrhage.

ABSTRACT:

Background

Liver disease is associated with altered serum osmolality, increased thrombin generation, and systemic inflammation, all of which may contribute to perihematomal edema (PHE) after intracerebral hemorrhage (ICH). We evaluated the association between a validated liver fibrosis index and PHE growth in a cohort of patients with primary ICH.

Methods

We performed a retrospective cohort study using data from the Virtual International Stroke Trials Archive-ICH. We included adult patients with primary ICH presenting within 6 h of symptom onset. The exposure of interest was the Fibrosis-4 (FIB-4) score, a validated liver fibrosis index; this was modeled as a continuous variable. The primary outcome was absolute PHE growth over 96 h. Secondary outcomes were absolute admissio

SUBMITTER: Parikh NS 

PROVIDER: S-EPMC7887133 | biostudies-literature | 2021 Jun

REPOSITORIES: biostudies-literature