Evidence for specificity of polygenic contributions to attainment in English, maths and science during adolescence.

ABSTRACT: How well one does at school is predictive of a wide range of important cognitive, socioeconomic, and health outcomes. The last few years have shown marked advancement in our understanding of the genetic contributions to, and correlations with, academic attainment. However, there exists a gap in our understanding of the specificity of genetic associations with performance in academic subjects during adolescence, a critical developmental period. To address this, the Avon Longitudinal Study of Parents and Children was used to conduct genome-wide association studies of standardised national English (N = 5983), maths (N = 6017) and science (N = 6089) tests. High SNP-based heritabilities (h²_SNP) for all subjects were found (41-53%). Further, h²_SNP for

SUBMITTER: Donati G 

PROVIDER: S-EPMC7887196 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature