Effects of open-label placebos in clinical trials: a systematic review and meta-analysis.

ABSTRACT: Open-label placebos (OLPs) are placebos without deception in the sense that patients know that they are receiving a placebo. The objective of our study is to systematically review and analyze the effect of OLPs in comparison to no treatment in clinical trials. A systematic literature search was carried out in February 2020. Randomized controlled trials of any medical condition or mental disorder comparing OLPs to no treatment were included. Data extraction and risk of bias rating were independently assessed. 1246 records were screened and thirteen studies were included into the systematic review. Eleven trials were eligible for meta-analysis. These trials assessed effects of OLPs on back pain, cancer-related fatigue, attention deficit hyperactivity disorder, allergic rhinitis, major depres

SUBMITTER: von Wernsdorff M 

PROVIDER: S-EPMC7887232 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature