Association of proton pump inhibitors and concomitant drugs with risk of acute kidney injury: a nested case-control study.

ABSTRACT:

Objectives

This study aimed to assess whether the combined use of proton pump inhibitors (PPIs) with non-steroidal anti-inflammatory drugs (NSAIDs) or antibiotics (penicillins, macrolides, cephalosporins or fluoroquinolones) was associated with an increased risk of acute kidney injury (AKI).

Design

A nested case-control study.

Setting

A health insurance claims database constructed by the Japan Medical Data Center.

Participants

Patients were eligible if they were prescribed a PPI, NSAID and antibiotic at least once between January 2005 and June 2017. The patients who were new PPI users and did not have any history of renal diseases before cohort entry were included (n=219 082). The mean age was 45 and 44% were women.

Interventions

Current use of PPIs, NSA

SUBMITTER: Ikuta K 

PROVIDER: S-EPMC7887345 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature