Mutant strains of SARS-CoV-2 are more prone to infect obese patient: a review.

ABSTRACT: The current review critically analyzes obesity as an important risk factor for increased predisposition towards coronavirus disease 2019 (COVID-19), its severity and causal death in current pandemic. Countries with higher prevalence of exposed obese individuals experienced the highest number of mortalities. The analysis also proved that individuals having more adipose tissue in body have a higher level of angiotensin-converting enzyme 2 (ACE2), which is identified as functional receptor for COVID-19. Therefore, obese individuals are worse in condition because of a higher presence of adiposity increases the number of ACE2 expressing cells. Furthermore, in silico interactions of ACE2 and different variants of coronavirus 2 (CoV-2) spike S1 protein suggest that mutant strains are more infecti

SUBMITTER: Ningombam SS 

PROVIDER: S-EPMC7887545 | biostudies-literature | 2021 Apr

REPOSITORIES: biostudies-literature