MnO₂ Nanoflowers Induce Immunogenic Cell Death under Nutrient Deprivation: Enabling an Orchestrated Cancer Starvation-Immunotherapy.

ABSTRACT: MnO₂ nanoparticles have been widely employed in cancer immunotherapy, playing a subsidiary role in assisting immunostimulatory drugs by improving their pharmacokinetics and/or creating a favorable microenvironment. Here, the stereotype of the subsidiary role of MnO₂ nanoparticles in cancer immunotherapy is challenged. This study unravels an intrinsic immunomodulatory property of MnO₂ nanoparticles as a unique nutrient-responsive immunogenic cell death (ICD) inducer, capable of directly modulating immunosurveillance toward tumor cells. MnO₂ nanoflowers (MNFs) constructed via a one pot self-assembly approach selectively induce ICD to nutrient-deprived but not nutrient-replete cancer cells, which is confirmed by the upregulated damage associated mol

SUBMITTER: Yang Y 

PROVIDER: S-EPMC7887587 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature