Cellular Pushing Forces during Mitosis Drive Mitotic Elongation in Collagen Gels.

ABSTRACT: Cell elongation along the division axis, or mitotic elongation, mediates proper segregation of chromosomes and other intracellular materials, and is required for completion of cell division. In three-dimensionally confining extracellular matrices, such as dense collagen gels, dividing cells must generate space to allow mitotic elongation to occur. In principle, cells can generate space for mitotic elongation during cell spreading, prior to mitosis, or via extracellular force generation or matrix degradation during mitosis. However, the processes by which cells drive mitotic elongation in collagen-rich extracellular matrices remains unclear. Here, it is shown that single cancer cells generate substantial pushing forces on the surrounding collagen extracellular matrix to drive cell division

SUBMITTER: Nam S 

PROVIDER: S-EPMC7887597 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature