A guide to understanding endoplasmic reticulum stress in metabolic disorders.

ABSTRACT:

Background

The global rise of metabolic disorders, such as obesity, type 2 diabetes, and cardiovascular disease, demands a thorough molecular understanding of the cellular mechanisms that govern health or disease. The endoplasmic reticulum (ER) is a key organelle for cellular function and metabolic adaptation and, therefore disturbed ER function, known as "ER stress," is a key feature of metabolic disorders.

Scope of review

As ER stress remains a poorly defined phenomenon, this review provides a general guide to understanding the nature, etiology, and consequences of ER stress in metabolic disorders. We define ER stress by its type of stressor, which is driven by proteotoxicity, lipotoxicity, and/or glucotoxicity. We discuss the implications of ER stress in metabolic disorde

SUBMITTER: Lemmer IL 

PROVIDER: S-EPMC7887651 | biostudies-literature | 2021 May

REPOSITORIES: biostudies-literature