The colorectal cancer-associated faecal microbiome of developing countries resembles that of developed countries.

ABSTRACT:

Background

The incidence of colorectal cancer (CRC) is increasing in developing countries, yet limited research on the CRC- associated microbiota has been conducted in these areas, in part due to scarce resources, facilities, and the difficulty of fresh or frozen stool storage/transport. Here, we aimed (1) to establish a broad representation of diverse developing countries (Argentina, Chile, India, and Vietnam); (2) to validate a 'resource-light' sample-collection protocol translatable in these settings using guaiac faecal occult blood test (gFOBT) cards stored and, importantly, shipped internationally at room temperature; (3) to perform initial profiling of the collective CRC-associated microbiome of these developing countries; and (4) to compare this quantitatively with establish

SUBMITTER: Young C 

PROVIDER: S-EPMC7887780 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature