Biological characteristics of stem cells derived from burned skin-a comparative study with umbilical cord stem cells.

ABSTRACT:

Introduction

Burned human skin, which is routinely excised and discarded, contains viable mesenchymal stromal/stem cells (burn-derived mesenchymal stromal/stem cells; BD-MSCs). These cells show promising potential to enable and aid wound regeneration. However, little is known about their cell characteristics and biological function.

Objectives

This study had two aims: first, to assess critical and cellular characteristics of BD-MSCs and, second, to compare those results with multipotent well-characterized MSCs from Wharton's jelly of human umbilical cords (umbilical cord mesenchymal stromal/stem cells, UC-MSCs).

Methods

BD- and UC-MSCs were compared using immunophenotyping, multi-lineage differentiation, seahorse analysis for glycolytic and mitochondrial function, imm

SUBMITTER: Dolp R 

PROVIDER: S-EPMC7888080 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature