Gut microbiota of patients with different subtypes of gastric cancer and gastrointestinal stromal tumors.

ABSTRACT:

Background

Gastric adenocarcinoma is associated with H. pylori infection and inflammation that can result in the dysbiosis of gastric microbiota. The association of intestinal microbiota with gastric adenocarcinoma subtypes or with gastric gastrointestinal stromal tumors (GIST) is however not well known. Therefore, we performed 16S rRNA gene sequencing on DNA isolated from stool samples of Finnish patients and controls to study differences in microbiota among different histological subtypes of gastric adenocarcinoma, gastric GIST and healthy controls.

Results

We found that gut microbiota alpha diversity was lowest in diffuse adenocarcinoma patients, followed by intestinal type and GIST patients, although the differences were not significant compared to controls. Beta-diversi

SUBMITTER: Sarhadi V 

PROVIDER: S-EPMC7888145 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature