The dysbiosis of ovine foot microbiome during the development and treatment of contagious ovine digital dermatitis.

ABSTRACT:

Background

Contagious Ovine Digital Dermatitis (CODD) is an emerging and common infectious foot disease of sheep which causes severe welfare and economic problems for the sheep industry. The aetiology of the disease is not fully understood and control of the disease is problematic. The aim of this study was to investigate the polybacterial aetiopathogenesis of CODD and the effects of antibiotic treatment, in a longitudinal study of an experimentally induced disease outbreak using a 16S rRNA gene amplicon sequencing approach.

Results

CODD was induced in 15/30 experimental sheep. During the development of CODD three distinct phenotypic lesion stages were observed. These were an initial interdigital dermatitis (ID) lesion, followed by a footrot (FR) lesion, then finally a CODD

SUBMITTER: Duncan JS 

PROVIDER: S-EPMC7888161 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature