Single-shot bevacizumab for cerebral radiation injury.

ABSTRACT:

Background

Cerebral radiation injury, including subacute radiation reactions and later stage radiation necrosis, is a severe side effect of brain tumor radiotherapy. A protocol of four infusions of the monoclonal antibody bevacizumab has been shown to be a highly effective treatment. However, bevacizumab is costly and can cause severe complications including thrombosis, bleeding and gastrointestinal perforations.

Methods

We performed a retrospective analysis of patients treated in our clinic for cerebral radiation injury who received only a singular treatment with bevacizumab. Single-shot was defined as a singular administration of bevacizumab without a second administration during an interval of at least 6 weeks.

Results

We identified 11 patients who had received a s

SUBMITTER: Voss M 

PROVIDER: S-EPMC7888179 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature