Reduced circulating dendritic cells in acute Plasmodium knowlesi and Plasmodium falciparum malaria despite elevated plasma Flt3 ligand levels.

ABSTRACT:

Background

Plasmodium falciparum malaria increases plasma levels of the cytokine Fms-like tyrosine kinase 3 ligand (Flt3L), a haematopoietic factor associated with dendritic cell (DC) expansion. It is unknown if the zoonotic parasite Plasmodium knowlesi impacts Flt3L or DC in human malaria. This study investigated circulating DC and Flt3L associations in adult malaria and in submicroscopic experimental infection.

Methods

Plasma Flt3L concentration and blood CD141⁺ DC, CD1c⁺ DC and plasmacytoid DC (pDC) numbers were assessed in (i) volunteers experimentally infected with P. falciparum and in Malaysian patients with uncomplicated (ii) P. falciparum or (iii) P. knowlesi malaria.

Results

Plasmodium knowlesi caused a decline in all circulating DC subs

SUBMITTER: Loughland JR 

PROVIDER: S-EPMC7888183 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature