Promoters adopt distinct dynamic manifestations depending on transcription factor context.

ABSTRACT: Cells respond to external signals and stresses by activating transcription factors (TF), which induce gene expression changes. Prior work suggests that signal-specific gene expression changes are partly achieved because different gene promoters exhibit distinct induction dynamics in response to the same TF input signal. Here, using high-throughput quantitative single-cell measurements and a novel statistical method, we systematically analyzed transcriptional responses to a large number of dynamic TF inputs. In particular, we quantified the scaling behavior among different transcriptional features extracted from the measured trajectories such as the gene activation delay or duration of promoter activity. Surprisingly, we found that even the same gene promoter can exhibit qualitatively disti

SUBMITTER: Hansen AS 

PROVIDER: S-EPMC7888307 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature