Australia IBD Microbiome (AIM) Study: protocol for a multicentre longitudinal prospective cohort study.

ABSTRACT:

Introduction

Crohn's disease and ulcerative colitis are common chronic idiopathic inflammatory bowel diseases (IBD), which cause considerable morbidity. Although the precise mechanisms of disease remain unclear, evidence implicates a strong multidirectional interplay between diet, environmental factors, genetic determinants/immune perturbations and the gut microbiota. IBD can be brought into remission using a number of medications, which act by suppressing the immune response. However, none of the available medications address any of the underlying potential mechanisms. As we understand more about how the microbiota drives inflammation, much interest has focused on identifying microbial signals/triggers in the search for effective therapeutic targets. We describe the establishment

SUBMITTER: Williams AJ 

PROVIDER: S-EPMC7888320 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature