Phytoplankton trigger the production of cryptic metabolites in the marine actinobacterium Salinispora tropica.

ABSTRACT: Filamentous members of the phylum Actinobacteria are a remarkable source of natural products with pharmaceutical potential. The discovery of novel molecules from these organisms is, however, hindered because most of the biosynthetic gene clusters (BGCs) encoding these secondary metabolites are cryptic or silent and are referred to as orphan BGCs. While co-culture has proven to be a promising approach to unlock the biosynthetic potential of many microorganisms by activating the expression of these orphan BGCs, it still remains an underexplored technique. The marine actinobacterium Salinispora tropica, for instance, produces valuable compounds such as the anti-cancer molecule salinosporamide but half of its putative BGCs are still orphan. Although previous studies have used marine heterotrop

SUBMITTER: Chhun A 

PROVIDER: S-EPMC7888443 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature