Test-retest reliability of the human functional connectome over consecutive days: identifying highly reliable portions and assessing the impact of methodological choices.

ABSTRACT: Countless studies have advanced our understanding of the human brain and its organization by using functional magnetic resonance imaging (fMRI) to derive network representations of human brain function. However, we do not know to what extent these "functional connectomes" are reliable over time. In a large public sample of healthy participants (N = 833) scanned on two consecutive days, we assessed the test-retest reliability of fMRI functional connectivity and the consequences on reliability of three common sources of variation in analysis workflows: atlas choice, global signal regression, and thresholding. By adopting the intraclass correlation coefficient as a metric, we demonstrate that only a small portion of the functional connectome is characterized by good (6-8%) to excellent

SUBMITTER: Tozzi SL 

PROVIDER: S-EPMC7888485 | biostudies-literature | 2020

REPOSITORIES: biostudies-literature