Societal challenges of precision medicine: Bringing order to chaos.

ABSTRACT: The increasing number of drugs targeting specific proteins implicated in tumourigenesis and the commercial promotion of relatively affordable genome-wide analyses has led to an increasing expectation among patients with cancer that they can now receive effective personalised treatment based on the often complex genomic signature of their tumour. For such approaches to work in routine practice, the development of correspondingly complex biomarker assays through an appropriate and rigorous regulatory framework will be required. It is becoming increasingly evident that a re-engineering of clinical research is necessary so that regulatory considerations and procedures facilitate the efficient translation of these required biomarker assays from the discovery setting through to clinical applicat

SUBMITTER: Salgado R 

PROVIDER: S-EPMC7888555 | biostudies-literature | 2017 Oct

REPOSITORIES: biostudies-literature