Recruitment of PP1 to the centrosomal scaffold protein CEP192.

ABSTRACT: Centrosomal protein of 192 kDa (CEP192) is a scaffolding protein that recruits the mitotic protein kinases Aurora A and PLK1 to the centrosome. Here we demonstrate that CEP192 also recruits the type one protein phosphatase (PP1) via a highly conserved KHVTF docking motif. The threonine of the KHVTF motif is phosphorylated during mitosis and protein kinase inhibition studies suggest this to be a PLK1-dependent process.

SUBMITTER: Nasa I 

PROVIDER: S-EPMC7888556 | biostudies-literature | 2017 Mar

REPOSITORIES: biostudies-literature