Colistin Nephrotoxicity: Meta-Analysis of Randomized Controlled Trials.

ABSTRACT:

Background

Nephrotoxicity is a known adverse effect of polymyxin antibiotics, including colistin. Although previous meta-analyses have aimed to characterize colistin-associated nephrotoxicity risk relative to other antibiotics, included studies were observational in nature with high risk of confounding and heterogeneity. We conducted this systematic review and meta-analysis of exclusively randomized controlled trials (RCTs) to evaluate the incidence of nephrotoxicity associated with colistin versus minimally nephrotoxic antibiotics.

Methods

We searched PubMed, EMBASE, Cochrane Library, and 3 trial registries for RCTs comparing the nephrotoxicity of colistin to nonpolymyxin antibiotics. Randomized controlled trials that used aminoglycosides were excluded. Risk ratios (RRs) an

SUBMITTER: Eljaaly K 

PROVIDER: S-EPMC7888569 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature