Identifying the drivers of multidrug-resistant Klebsiella pneumoniae at a European level.

ABSTRACT: Beta-lactam- and in particular carbapenem-resistant Enterobacteriaceae represent a major public health threat. Despite strong variation of resistance across geographical settings, there is limited understanding of the underlying drivers. To assess these drivers, we developed a transmission model of cephalosporin- and carbapenem-resistant Klebsiella pneumoniae. The model is parameterized using antibiotic consumption and demographic data from eleven European countries and fitted to the resistance rates for Klebsiella pneumoniae for these settings. The impact of potential drivers of resistance is then assessed in counterfactual analyses. Based on reported consumption data, the model could simultaneously fit the prevalence of extended-spectrum beta-lactamase-producing and carbapenem-resistant

SUBMITTER: Kachalov VN 

PROVIDER: S-EPMC7888642 | biostudies-literature | 2021 Jan

REPOSITORIES: biostudies-literature