Parkinson's disease medication state and severity assessment based on coordination during walking.

ABSTRACT: Walking is a complex motor function requiring coordination of all body parts. Parkinson's disease (PD) motor signs such as rigidity, bradykinesia, and impaired balance affect movements including walking. Here, we propose a computational method to objectively assess the effects of Parkinson's disease pathology on coordination between trunk, shoulder and limbs during the gait cycle to assess medication state and disease severity. Movements during a scripted walking task were extracted from wearable devices placed at six different body locations in participants with PD and healthy participants. Three-axis accelerometer data from each device was synchronized at the beginning of either left or right steps. Canonical templates of movements were then extracted from each body location. Movements p

SUBMITTER: Agurto C 

PROVIDER: S-EPMC7888646 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature