Feasibility of integrating canine olfaction with chemical and microbial profiling of urine to detect lethal prostate cancer.

ABSTRACT: Prostate cancer is the second leading cause of cancer death in men in the developed world. A more sensitive and specific detection strategy for lethal prostate cancer beyond serum prostate specific antigen (PSA) population screening is urgently needed. Diagnosis by canine olfaction, using dogs trained to detect cancer by smell, has been shown to be both specific and sensitive. While dogs themselves are impractical as scalable diagnostic sensors, machine olfaction for cancer detection is testable. However, studies bridging the divide between clinical diagnostic techniques, artificial intelligence, and molecular analysis remains difficult due to the significant divide between these disciplines. We tested the clinical feasibility of a cross-disciplinary, integrative approach to early prostate

SUBMITTER: Guest C 

PROVIDER: S-EPMC7888653 | biostudies-literature | 2021

REPOSITORIES: biostudies-literature