Reproduction of patterns in melanocytic proliferations by agent-based simulation and geometric modeling.

ABSTRACT: Spatio-temporal patterns of melanocytic proliferations observed in vivo are important for diagnosis but the mechanisms that produce them are poorly understood. Here we present an agent-based model for simulating the emergence of the main biologic patterns found in melanocytic proliferations. Our model portrays the extracellular matrix of the dermo-epidermal junction as a two-dimensional manifold and we simulate cellular migration in terms of geometric translations driven by adhesive, repulsive and random forces. Abstracted cellular functions and melanocyte-matrix interactions are modeled as stochastic events. For identification and validation we use visual renderings of simulated cell populations in a horizontal perspective that reproduce growth patterns observed in vivo by sequential derm

SUBMITTER: Schneckenreither G 

PROVIDER: S-EPMC7888658 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature