Post-transcriptional regulation by the exosome complex is required for cell survival and forebrain development via repression of P53 signaling.

ABSTRACT: Fine-tuned gene expression is crucial for neurodevelopment. The gene expression program is tightly controlled at different levels, including RNA decay. N⁶-methyladenosine (m6A) methylation-mediated degradation of RNA is essential for brain development. However, m6A methylation impacts not only RNA stability, but also other RNA metabolism processes. How RNA decay contributes to brain development is largely unknown. Here, we show that Exosc10, a RNA exonuclease subunit of the RNA exosome complex, is indispensable for forebrain development. We report that cortical cells undergo overt apoptosis, culminating in cortical agenesis upon conditional deletion of Exosc10 in mouse cortex. Mechanistically, Exosc10 directly binds and degrades transcripts of the P53 signaling-related genes, su

SUBMITTER: Ulmke PA 

PROVIDER: S-EPMC7888709 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature