Perinatal granulopoiesis and risk of pediatric asthma.

ABSTRACT: There are perinatal characteristics, such as gestational age, reproducibly associated with the risk for pediatric asthma. Identification of biologic processes influenced by these characteristics could facilitate risk stratification or new therapeutic targets. We hypothesized that transcriptional changes associated with multiple epidemiologic risk factors would be mediators of pediatric asthma risk. Using publicly available transcriptomic data from cord blood mononuclear cells, transcription of genes involved in myeloid differentiation was observed to be inversely associated with a pediatric asthma risk stratification based on multiple perinatal risk factors. This gene signature was validated in an independent prospective cohort and was specifically associated with genes localizing to neutr

SUBMITTER: Turturice BA 

PROVIDER: S-EPMC7889076 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature