Intestinal Inflammation as a Dysbiosis of Energy Procurement: New Insights into an Old Topic.

ABSTRACT: Inflammatory bowel disease (IBD) coincides with profound shifts in microbiota and host metabolic energy supply and demand. The gastrointestinal epithelium is anatomically positioned to provide a selective barrier between the anaerobic luminal microbiota and host lamina propria, with the microbiota and epithelium participating in an intricate energy exchange necessary for homeostasis. Maintenance and restoration of the barrier requires high energy flux and places significant demands on available substrates to generate ATP. It is recently appreciated that components of the microbiota contribute significantly to a multitude of biochemical pathways within and outside of the mucosa. Decades-old studies have appreciated that byproducts of the microbiota provide essential sources of energy to the

SUBMITTER: Lee JS 

PROVIDER: S-EPMC7889129 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature