B. adolescentis ameliorates chronic colitis by regulating Treg/Th2 response and gut microbiota remodeling.

ABSTRACT: Inflammatory bowel disease (IBD) is defined as an immune dysregulation disease with poor prognosis. Various therapies based on gut microbe modulation have been proposed. In this study, we aim to explore the therapeutic effect of B. adolescentis on IBD, as well as the immune and microecology mechanism of B. adolescentis in IBD. The fecal level of B. adolescentis was decreased in the IBD patients compared with the normal people in our cohort and the GMrepo database. To further clarify the role of B. adolescentis in IBD, we induced chronic colitis with three cycles of dextran sulfate sodium (DSS). We found B. adolescentis gavage exhibited protective effects as evidenced by the significantly decreased diarrhea score, spleen weight, and increased colon length.

SUBMITTER: Fan L 

PROVIDER: S-EPMC7889144 | biostudies-literature | 2021 Jan-Dec

REPOSITORIES: biostudies-literature