Ontology highlight
ABSTRACT:
SUBMITTER: Singh AK
PROVIDER: S-EPMC7889220 | biostudies-literature | 2021 Jan-Feb
REPOSITORIES: biostudies-literature
Singh Anup Kumar AK Verma Ayushi A Singh Akhilesh A Arya Rakesh Kumar RK Maheshwari Shrankhla S Chaturvedi Priyank P Nengroo Mushtaq Ahmad MA Saini Krishan Kumar KK Vishwakarma Achchhe Lal AL Singh Kavita K Sarkar Jayanta J Datta Dipak D
Epigenetics 20200708 2
Drug resistance is one of the trademark features of Cancer Stem Cells (CSCs). We and others have recently shown that paucity of functional death receptors (DR4/5) on the cell surface of tumour cells is one of the major reasons for drug resistance, but their involvement in the context of in CSCs is poorly understood. By harnessing CSC specific cytotoxic function of salinomycin, we discovered a critical role of epigenetic modulator EZH2 in regulating the expression of DRs in colon CSCs. Our unbias ...[more]