Dataset Information

Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer.

ABSTRACT: Buruli ulcer (BU) is a devastating skin mycobacterial infection characterized by extensive cell death, which was previously suggested to be mediated by Bcl2-like protein 11 (BIM, encoded by the BCL2L11 gene). We here report the association of genetic variants in BCL2L11 with ulcerative forms of the disease in a cohort of 618 Beninese individuals. Our results show that regulation of apoptosis in humans contributes to BU lesions associated with worse prognosis, prompting for further investigation on the implementation of novel methods for earlier identification of at-risk patients.

SUBMITTER: Fevereiro J

PROVIDER: S-EPMC7889264 | biostudies-literature | 2021 Dec

REPOSITORIES: biostudies-literature

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Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer.

Fevereiro João J Fraga Alexandra G AG Capela Carlos C Sopoh Ghislain E GE Dossou Ange A Ayelo Gilbert Adjimon GA Peixoto Maria João MJ Cunha Cristina C Carvalho Agostinho A Rodrigues Fernando F Pedrosa Jorge J

Emerging microbes & infections 20211201 1

Buruli ulcer (BU) is a devastating skin mycobacterial infection characterized by extensive cell death, which was previously suggested to be mediated by Bcl2-like protein 11 (BIM, encoded by the BCL2L11 gene). We here report the association of genetic variants in BCL2L11 with ulcerative forms of the disease in a cohort of 618 Beninese individuals. Our results show that regulation of apoptosis in humans contributes to BU lesions associated with worse prognosis, prompting for further ...[more]

PMID: 33467983

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Project description:BackgroundIn the Cameroon, previous efforts to identify Buruli ulcer (BU) through the mobilization of community health workers (CHWs) yielded poor results. In this paper, we describe the successful creation of a BU community of practice (BUCOP) in Bankim, Cameroon composed of hospital staff, former patients, CHWs, and traditional healers.Methods and principle findingsAll seven stages of a well-defined formative research process were conducted during three phases of research carried out by a team of social scientists working closely with Bankim hospital staff. Phase one ethnographic research generated interventions tested in a phase two proof of concept study followed by a three- year pilot project. In phase three the pilot project was evaluated. An outcome evaluation documented a significant rise in BU detection, especially category I cases, and a shift in case referral. Trained CHW and traditional healers initially referred most suspected cases of BU to Bankim hospital. Over time, household members exposed to an innovative and culturally sensitive outreach education program referred the greatest number of suspected cases. Laboratory confirmation of suspected BU cases referred by community stakeholders was above 30%. An impact and process evaluation found that sustained collaboration between health staff, CHWs, and traditional healers had been achieved. CHWs came to play a more active role in organizing BU outreach activities, which increased their social status. Traditional healers found they gained more from collaboration than they lost from referral.Conclusion/ significanceSetting up lines of communication, and promoting collaboration and trust between community stakeholders and health staff is essential to the control of neglected tropical diseases. It is also essential to health system strengthening and emerging disease preparedness. The BUCOP model described in this paper holds great promise for bringing communities together to solve pressing health problems in a culturally sensitive manner.

Dataset Information

Genetic variants in human BCL2L11 (BIM) are associated with ulcerative forms of Buruli ulcer.

Publications

Genetic variants in human <i>BCL2L11</i> (<i>BIM</i>) are associated with ulcerative forms of Buruli ulcer.

Similar Datasets

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