Genetic variants in m⁶A modification core genes are associated with glioma risk in Chinese children.

ABSTRACT: Glioma is a highly heritable disease with a strong genetic component. The N6-methyladenosine (m⁶A) modification core genes play important roles in the context of cancer. However, the effects of polymorphisms in the m⁶A modification core genes on the risk of pediatric glioma remain undefined. Here, we intended to demonstrate the relationship between 24 functional single-nucleotide polymorphisms (SNPs) in eight m⁶A modification core genes and glioma risk. Case-control design and multinomial logistic regression were used to develop models to estimate the risk of glioma while accounting for the subtypes of glioma. A total of 171 glioma cases and 228 controls from South China were genotyped using a TaqMan assay. The WTAP rs7766006, YTHDF2 rs3738067, and F

SUBMITTER: He J 

PROVIDER: S-EPMC7889446 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature