Metabolomic analysis of Trichophyton rubrum and Microsporum canis during keratin degradation.

ABSTRACT: Keratin is important and needed for the growth of dermatophytes in the host tissue. In turn, the ability to invade keratinised tissues is defined as a pivotal virulence attribute of this group of medically important fungi. The host-dermatophyte interaction is accompanied by an adaptation of fungal metabolism that allows them to adhere to the host tissue as well as utilize the available nutrients necessary for their survival and growth. Dermatophyte infections pose a significant epidemiological and clinical problem. Trichophyton rubrum is the most common anthropophilic dermatophyte worldwide and its typical infection areas include skin of hands or feet and nail plate. In turn, Microsporum canis is a zoophilic pathogen, and mostly well known for ringworm in pets, it is also known to infect h

SUBMITTER: Ciesielska A 

PROVIDER: S-EPMC7889620 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature