Complex precursor structures of cytolytic cupiennins identified in spider venom gland transcriptomes.

ABSTRACT: Analysis of spider venom gland transcriptomes focuses on the identification of possible neurotoxins, proteins and enzymes. Here, the first comprehensive transcriptome analysis of cupiennins, small linear cationic peptides, also known as cytolytic or antimicrobial peptides, is reported from the venom gland transcriptome of Cupiennius salei by 454- and Illumina 3000 sequencing. Four transcript families with complex precursor structures are responsible for the expression of 179 linear peptides. Within the transcript families, after an anionic propeptide, cationic linear peptides are separated by anionic linkers, which are transcript family specific. The C-terminus of the transcript families is characterized by a linear peptide or truncated linkers with unknown function. A new identified postt

SUBMITTER: Kuhn-Nentwig L 

PROVIDER: S-EPMC7889660 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature