Dopamine D_2/3 receptor availability in cocaine use disorder individuals with obesity as measured by [¹¹C]PHNO PET.

ABSTRACT:

Background

Positron emission tomography (PET) work with the dopamine D3 receptor (D₃R) preferring ligand [¹¹C]PHNO in obese individuals has demonstrated higher binding and positive correlations with body mass index (BMI) in otherwise healthy individuals. These findings implicated brain reward areas including the substantia nigra/ventral tegmental area (SN/VTA) and pallidum. In cocaine use disorder (CUD), similar SN/VTA binding profiles have been found compared to healthy control subjects. This study investigates whether BMI-[¹¹C]PHNO relationships are similar in individuals with CUD.

Methods

Non-obese CUD subjects (N = 12) were compared to age-matched obese CUD subjects (N = 14). All subjects underwent [¹¹C]PHNO acquisition using a

SUBMITTER: Matuskey D 

PROVIDER: S-EPMC7889720 | biostudies-literature | 2021 Mar

REPOSITORIES: biostudies-literature