Cell-type-specific asynchronous modulation of PKA by dopamine in learning.

ABSTRACT: Reinforcement learning models postulate that neurons that release dopamine encode information about action and action outcome, and provide a teaching signal to striatal spiny projection neurons in the form of dopamine release¹. Dopamine is thought to guide learning via dynamic and differential modulation of protein kinase A (PKA) in each class of spiny projection neuron². However, the real-time relationship between dopamine and PKA in spiny projection neurons remains untested in behaving animals. Here we monitor the activity of dopamine-releasing neurons, extracellular levels of dopamine and net PKA activity in spiny projection neurons in the nucleus accumbens of mice during learning. We find positive and negative modulation of dopamine that evolves across training an

SUBMITTER: Lee SJ 

PROVIDER: S-EPMC7889726 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature