Theranostic SPECT reconstruction for improved resolution: application to radionuclide therapy dosimetry.

ABSTRACT:

Background

SPECT-derived dose estimates in tissues of diameter less than 3× system resolution are subject to significant losses due to the limited spatial resolution of the gamma camera. Incorporating resolution modelling (RM) into the SPECT reconstruction has been proposed as a possible solution; however, the images produced are prone to noise amplification and Gibbs artefacts. We propose a novel approach to SPECT reconstruction in a theranostic setting, which we term SPECTRE (single photon emission computed theranostic reconstruction); using a diagnostic PET image, with its superior resolution, to guide the SPECT reconstruction of the therapeutic equivalent. This report demonstrates a proof in principle of this approach.

Methods

We have employed the hybrid kernelised expec

SUBMITTER: Marquis H 

PROVIDER: S-EPMC7889770 | biostudies-literature | 2021 Feb

REPOSITORIES: biostudies-literature